One of the fundamental achievements of the science of man at the turn of the XX-XXI centuries is the “Reflexional psychology of Vladimir Lefevbre” (Wheeler, 1990). It is the result of interdisciplinary synthesis of an array of the emerged in the XXth century reflexional sciences: logics, semiotics, psychology, conflictology, ethics, management, politology, systems science, cybernetics, physics, mathematics, cosmology. The Russian-American scientist V.A. Lefevbre contributed to each of them. V.A. Lefevbre has the Renaissant range of research interests, phenomenal creativity, encyclopeadism of professional activity. The research objective of this article is the analysis of V.A. Lefevbre’s trajectory of life and his creative achievements in the field of interdisciplinary studies of such complex psychological reality as reflexivity. For the first time the personological periodization of V.A. Lefevbre’s life was suggested, the development of his personality in three key periods of his work (Soviet, American, Transatlantic) was characterized, the analysis of his scientific achievements was conducted. The constructivity of V.A. Lefevbre’s systematic interdisciplinary approach to the study and learning of reflexive processes in the context of the modern development of science and society is shown. The novelty of the results from the study of V.A. Lefevbre’s creative life is determined by the systematic methodology of his reflexive-scientific studies according to the complementarity principle. This principle is realized by means of interaction of personological approach to characteristics of V.A. Lefevbre’s creative personality and scientific approach to the analysis of his innovative scientific work in the contemporary sociocultural context of development of science and society. In the end, the fundamental significance of V.A. Lefevbre’s interdisciplinary works for the study of reflexion on a scale of science of man and cosmology is shown.