While negative psychological effects of COVID-19 pandemic are actively studied, little is known about the eventual positive reactions to the pandemic including the capacity to see positive opportunities in this situation and about personality resources that may help to cope and to maintain well-being despite lifestyle restrictions. The aim of our study was to reveal positive personality resources that contribute to buffering the negative effects and its consequences on individual lives. 474 adults 18-81 years old from Siberia (Russia) participated in May 2020 in a survey about the impact of the pandemic and self-isolation and also filled out psychometric measures of well-being and psychological resources (PANAS, PWI, Value of Life Scale, MHC, MSTAT-I, LOT, GSE, Hardiness Survey, SOC, Personal Life Position inventory). One in three respondents reported worsening emotional condition through the previous two weeks and poor adherence to governmental self-isolation recommendations, and 43.6% reported increased financial difficulties. Taking into account not only the negative but also positive subjective effect of the pandemic enabled the improved accuracy in prediction of both well-being and adherence to the governmental measures. The less a person mentioned the positive side of the pandemic, the more strongly their adherence to the governmental measures depended on perceived negative effects (worries and threats). Tolerance for ambiguity, the challenge component of hardiness, harmony with life predicted perceived positive effects after adjusting for negative effects. Psychological resources could play a buffering role as regards the vulnerability to negative psychological effects of the pandemic and help to find positive opportunities.