The article presents a consonant-vowel (CV) syllables dichotic listening task that was developed considering phonetic features of the Russian language as a subtler tool for evaluation of the brain lesion lateralization. The study described a pilot approbation of the CV syllables test in normal controls and left- and right-brain injured patients. The study employed both words and CV syllables dichotic listening tests. The CV syllables dichotic listening task is a reliable and representative method, however it didn’t show normal distribution. The word and the CV syllables tests are oriented to the evaluation of different mental processes: word dichotic listening is in essence a working memory paradigm, while the CV syllables task estimates audioverbal interhemisphere asymmetry. Confounded factors such as individual strategies, attentional biases, the order in which the items were reported and working memory (short-term) were undercut and/or eliminated in the CV syllables task in comparison with the word test. Compared to the dichotic words test, the consonant-vowel syllables dichotic listening test turned out to be a more sensitive instrument which showed significant differences between healthy participants and the brain-injured patients, as well as the differences between the right brain-injured patients and the left brain-injured ones. The findings are consistent with the approved scientific data.